Anti-Acetyl CoA Carboxylase 1 (ACC1) Antibody [ST53-08]

HUABIO

Anti-Acetyl CoA Carboxylase 1 (ACC1) Antibody [ST53-08]

7

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P

Research Use Only

Monoclonal

ST53-08

1 mg/ml

Unconjugated

ACACA

acetyl-CoA carboxylase alpha

ACAC, ACACAD, ACACalpha, ACC, ACC1, ACCA, ACCalpha, Acac1, hACC1, acetyl-CoA carboxylase 1, ACC-alpha, acetyl-Coenzyme A carboxylase alpha

Rabbit

IgG

Acetyl-CoA carboxylase 1

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACCalpha (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCbeta (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCalpha is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzymes short-term regulatory mechanism. The gene encoding ACCalpha maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCbeta is homologous to that of the ACCalpha, except for an additional peptide of about 150 amino acids at the N-terminus.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161