Anti-Acetyl-Histone H2B (Lys12) Rabbit pAb

PTM BIO

Anti-Acetyl-Histone H2B (Lys12) Rabbit pAb

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Anti-Acetyl-Histone H2B (Lys12) Rabbit pAb detects histone H2B only when it is acetylated at Lys12. This antibody has been shown to selectively recognize acetylated H2B peptide at Lys12, but not the structurally similar crotonylated peptides at Lys11 or Lys12.

Western Blot, ChIP Chromatin ImmunoPrecipitation

WB, ChIP

Antibody

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Histone H2B type 1-C/E/F/G/I

Histone post-translational modifications (PTMs), known as the “histone code”, are key mechanisms of epigenetics that modulate chromatin structures. The PTMs on histone including acetylation, methylation, Phosphorylatedrylation, and novel acylations directly affect the accessibility of chromatin to transcription factors and other epigenetic regulators, altering genome stability and gene transcription. Histone acetylation, tightly controlled by the opposing action of histone acetyltransferases (HATs) and histone deacetylases (HDACs), occurs primarily at lysine residues on the N-terminal tails of histones H2A (Lys5, 9, and 15), H2B (Lys5,12, 15, 16, and 20), H3 (Lys4, 9, 14, 18, 23, 27, and 36), and H4 (Lys5, 8, 12, 16, and 20), and plays vital roles in the regulation of gene expression, DNA damage repair, chromatin dynamics, etc.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein A and immunogen affinity purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203