Anti-Acetyl-Histone H3 (Lys36) Rabbit pAb
PTM-117
ApplicationsImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
Overview
- SupplierPTM BIO
- Product NameAnti-Acetyl-Histone H3 (Lys36) Rabbit pAb
- Delivery Days Customer5
- Antibody SpecificityAnti-Acetyl-Histone H3 (Lys36) Rabbit pAb detects histone H3 only when it is acetylated at Lys36. This antibody has been shown to selectively recognize acetylated H3 peptide at Lys36, but not the unmodified peptide.
- ApplicationsImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin
- Applications SupplierWB, IHC-P, ICC/IF, ChIP
- Category SupplierAntibody
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- HostRabbit
- IsotypeIgG
- Protein IDP68431
- Protein NameHistone H3.1
- Scientific DescriptionHistone post-translational modifications (PTMs), known as the “histone code”, are key mechanisms of epigenetics that modulate chromatin structures. The PTMs on histone including acetylation, methylation, Phosphorylatedrylation, and novel acylations directly affect the accessibility of chromatin to transcription factors and other epigenetic regulators, altering genome stability and gene transcription. Histone acetylation, tightly controlled by the opposing action of histone acetyltransferases (HATs) and histone deacetylases (HDACs), occurs primarily at lysine residues on the N-terminal tails of histones H2A (Lys5, 9, and 15), H2B (Lys5,12, 15, 16, and 20), H3 (Lys4, 9, 14, 18, 23, 27, and 36), and H4 (Lys5, 8, 12, 16, and 20), and plays vital roles in the regulation of gene expression, DNA damage repair, chromatin dynamics, etc.
- Shelf life instructionStable for 12 months from date of receipt/reconstitution.
- ReactivityHuman, Mouse, Rat
- Reactivity SupplierHuman, Mouse, Rat
- Reactivity Supplier NoteProtein A and immunogen affinity purified
- Storage InstructionStore at -20°C. Avoid freeze/thaw cycles.
- UNSPSC12352203
References
- Xiaoyang Chen, et al. 'A secreted fungal effector suppresses rice immunity through host histone hypoacetylation' NEW PHYTOLOGIST (2022)Read more
- Chao Xue, et al. 'Global Proteome Analysis Links Lysine Acetylation to Diverse Functions in Oryza Sativa' PROTEOMICS (2017)Read more
- Xiaoyang Chen, et al. 'Ustilaginoidea virens-secreted effector Uv1809 suppresses rice immunity by enhancing OsSRT2-mediated histone deacetylation' PLANT BIOTECHNOLOGY JOURNAL (2023)Read more