Anti-acetylcholine receptor [mAb198]

Absolute Antibody

Anti-acetylcholine receptor [mAb198]

9

The specificity of this antibody for the major immunogenic region of human acetylcholine receptor has been confirmed in Western blot and ELISA analysis (Barchan et al, 1998). This antibody cross-links acetylcholine receptors on the muscle surface and promotes their degradation; incubation of AChR-expressing cell lines with mAb198 results in a reduction in AChR (Barchan et al, 1988). Indeed, administration of this antibody to mice is sufficient to induce experimental autoimmune myasthenia gravis (EAMG), a neuromuscular disorder arising from a reduction in available acetylcholine receptors at the NMJ (Asher, 1993).

ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry, Other Application

Research Use Only

Monoclonal

mAb198

CHRNA1

cholinergic receptor nicotinic alpha 1 subunit

ACHRA, ACHRD, CHRNA, CMS1A, CMS1B, CMS2A, FCCMS, SCCMS, acetylcholine receptor subunit alpha, acetylcholine receptor, nicotinic, alpha 1 (muscle), cholinergic receptor, nicotinic alpha 1, cholinergic receptor, nicotinic, alpha 1 (muscle), cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle), muscle nicotinic acetylcholine receptor, nicotinic acetylcholine receptor alpha subunit, nicotinic cholinergic receptor alpha 1

Rat

IgG2a

Acetylcholine receptor subunit alpha

Human

-20°C,2°C to 8°C

12352203