Anti-ACY1 Antibody [15G2]

HUABIO

Anti-ACY1 Antibody [15G2]

7

Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P,FC

Research Use Only

Monoclonal

15G2

2 mg/ml

Unconjugated

ACY1

aminoacylase 1

ACY-1, ACY1D, HEL-S-5, aminoacylase-1, N-acyl-L-amino-acid amidohydrolase, acylase, epididymis secretory protein Li 5

Mouse

IgG2a

Aminoacylase-1

Aminoacylase is involved in the regulation of the urea cycle. N-acetyl-L-glutamate is an allosteric activator of carbamoyl phosphate synthetase, a crucial enzyme that commits NH4+ molecules to the urea cycle. The urea cycle gets rid of excess ammonia (NH4+) in the body, a process that must be up-regulated during times of increased protein catabolism, as amino acid breakdown produces large amounts of NH4+. When amino acid catabolism increases, N-Acetylglutamate synthase is up-regulated, producing more N-acetyl-L-glutamate, which up-regulates carbamoyl phosphate synthetase and allows it to dispose of the excess NH4+ from catabolism.Aminoacylase is up-regulated during times of nutrient deficit or starvation, causing N-acetyl-L-glutamate breakdown, which down-regulates carbamoyl phosphate synthetase and the rest of the urea cycle. This response is evolutionarily advantageous, since a nutrient deficit means there isnt as much NH4+ that needs to be disposed of and since the body wants to salvage as many amino acids as it can.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161