Anti AGEs mAb (Clone 6D12)

Cosmo Bio USA

Anti AGEs mAb (Clone 6D12)

16

Research Use Only

Reaction of protein amino groups with glucose leads, through the early products such as a Schiff base and Amadori rearrangement products, to the formation of advanced glycation end products (AGEs). Recent immunological studies using anti-AGEs antibody (6D12) demonstrated the presence of AGEs-modified proteins in several human tissues: human lens (nondiabetic and noncataractous), ( patients with diabetic nephropathy and chronic renal failure, renal proximal tubules in diabetic retina, diabetic neuropathy, atherosclerotic lesions of arterial walls, peripheral nerves of 2-microglobulin forming amyloid fibrils in patients with hemodialysis-related amyloidosis, the peritoneum of CAPD patients, senile plaques of patients with Alzheimers disease, ( ) skin elastin in actinic elastosis, andceriod/lipofuscin deposits. These results suggest a potential role of AGEs-modification in normal aging as well as age-enhanced disease processes. This antibody named as 6D12 has been used to demonstrate AGEs-modified proteins in these human tissues, indicating potential usefulness of this antibody for histochemical identification and biochemical quantification of AGEs-modified proteins.

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