Anti Aldo-Keto Reductase Family 7 Member A3 (AKR7A3) central region mAb (Clone 2B8)

Cosmo Bio USA

Anti Aldo-Keto Reductase Family 7 Member A3 (AKR7A3) central region mAb (Clone 2B8)

16

Research Use Only

UniPlot Summary Function// Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Subunit structure// Homodimer. Subcellular location// Cytoplasm. Tissue specificity// Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium. Sequence similarities// Belongs to the aldo/keto reductase 2 family. Reference 1. cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3. Knight L.P.et al. Carcinogenesis 20:1215-1223(1999) [PubMed: 10383892] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANTS MET-138; ASP-215 AND ALA-323. Tissue: Liver. 2. Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells. Praml C.et al. Oncogene 22:4765-4773(2003) [PubMed: 12879023] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS ASP-215 AND ALA-323. 3. The DNA sequence and biological annotation of human chromosome 1. Gregory S.G. et al. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]

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