Anti-ALIX Rabbit mAb

PTM BIO

Anti-ALIX Rabbit mAb

5

ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P, IP

Research Use Only

Monoclonal

JRMR-10909-14

Unconjugated

Rabbit

IgG

Programmed cell death 6-interacting protein

Programmed cell death 6-interacting protein (PDCD6IP), plays an important role in the endosomal sorting complexes required for transport (ESCRT) pathway in the abscission stage of cytokinesis and apoptosis. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the protein binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. It also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this protein and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203