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Immunohistochemical staining of formalin fixed and paraffin embedded human brain tissue section using anti-ALK rabbit monoclonal antibody (Clone RM361) at a 1:1000 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human brain tissue section using anti-ALK rabbit monoclonal antibody (Clone RM361) at a 1:1000 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human brain tissue section using anti-ALK rabbit monoclonal antibody (Clone RM361) at a 1:1000 dilution.

anti-ALK (human), Rabbit Monoclonal (RM361)

Research Use Only
REV-31-1247-00
RevMAb Biosciences
ApplicationsImmunoHistoChemistry, Western Blot
Product group Antibodies
ReactivityHuman
TargetALK
Price on request
Packing Size
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Overview

  • Supplier
    RevMAb Biosciences
  • Product Name
    anti-ALK (human), Rabbit Monoclonal (RM361)
  • Delivery Days Customer
    5
  • Applications
    ImmunoHistoChemistry, Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    RM361
  • Gene ID238
  • Target name
    ALK
  • Target description
    ALK receptor tyrosine kinase
  • Target synonyms
    ALK tyrosine kinase receptor; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; mutant anaplastic lymphoma kinase; NBLST3
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    ALK was a novel receptor tyrosine kinase (RTK), having an extracellular ligand-binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain. While the tyrosine kinase domain of human ALK shares a high degree of similarity with that of the insulin receptor, its extracellular domain is unique among the RTK family in containing two MAM domains (meprin, A5 protein and receptor protein tyrosine phosphatase mu), an LDLa domain (low-density lipoprotein receptor class A) and a glycine-rich region. Following binding of the ligand, the full-length receptor ALK dimerizes, changes conformation, and autoactivates its own kinase domain, which in turn phosphorylates other ALK receptors in trans on specific tyrosine amino acid residues. ALK phosphorylated residues serve as binding sites for the recruitment of several adaptor and other cellular proteins, such as GRB2, IRS1, Shc, Src, FRS2, PTPN11/Shp2, PLCgamma, PI3K and NF1. Other reported downstream ALK targets include FOXO3a, CDKN1B/p27kip, cyclin D2, NIPA, RAC1, CDC42, p130CAS, SHP1 and PIKFYVE. Phosphorylated ALK activates multiple downstream signal transduction pathways, including MAPK-ERK, PI3K-AKT, PLCgamma, CRKL-C3G and JAK-STAT. The receptor ALK plays a pivotal role in cellular communication and in the normal development and function of the nervous system. Oncogenic ALK is expressed and used as a marker in anaplastic large-cell lymphomas (ALCLs) and non-small-cell lung cancer (NSCLC). - Recombinant Antibody. This antibody reacts human total ALK protein including ALK fusion proteins. Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. ALK was a novel receptor tyrosine kinase (RTK), having an extracellular ligand-binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain. While the tyrosine kinase domain of human ALK shares a high degree of similarity with that of the insulin receptor, its extracellular domain is unique among the RTK family in containing two MAM domains (meprin, A5 protein and receptor protein tyrosine phosphatase mu), an LDLa domain (low-density lipoprotein receptor class A) and a glycine-rich region. Following binding of the ligand, the full-length receptor ALK dimerizes, changes conformation, and autoactivates its own kinase domain, which in turn phosphorylates other ALK receptors in trans on specific tyrosine amino acid residues. ALK phosphorylated residues serve as binding sites for the recruitment of several adaptor and other cellular proteins, such as GRB2, IRS1, Shc, Src, FRS2, PTPN11/Shp2, PLCgamma, PI3K and NF1. Other reported downstream ALK targets include FOXO3a, CDKN1B/p27kip, cyclin D2, NIPA, RAC1, CDC42, p130CAS, SHP1 and PIKFYVE. Phosphorylated ALK activates multiple downstream signal transduction pathways, including MAPK-ERK, PI3K-AKT, PLCgamma, CRKL-C3G and JAK-STAT. The receptor ALK plays a pivotal role in cellular communication and in the normal development and function of the nervous system. Oncogenic ALK is expressed and used as a marker in anaplastic large-cell lymphomas (ALCLs) and non-small-cell lung cancer (NSCLC).
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203