Anti-Alpha Actinin 2 Antibody [JF0980]

HUABIO

Anti-Alpha Actinin 2 Antibody [JF0980]

7

ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P,IP

Research Use Only

Monoclonal

JF0980

1 mg/ml

Unconjugated

ACTN2

actinin alpha 2

CMD1AA, CMH23, CMYO8, CMYP8, MPD6, MYOCOZ, alpha-actinin-2, F-actin cross-linking protein, alpha-actinin skeletal muscle

Rabbit

IgG

Alpha-actinin-2

The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and alpha-actinins. There are four tissue-specific alpha-actinins, namely alpha-actinin-1, alpha-actinin-2, alpha-actinin-3 and alpha-actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each alpha-actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding alpha-actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161