Anti-Alpha B Crystallin Antibody [JA50-32]

HUABIO

Anti-Alpha B Crystallin Antibody [JA50-32]

7

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P,IF-Cell,IF-Tissue,IP

Research Use Only

Monoclonal

JA50-32

1 mg/ml

Unconjugated

CRYAB

crystallin alpha B

CMD1II, CRYA2, CTPP2, CTRCT16, HEL-S-101, HSPB5, MFM2, MFM2A, MFM2B, alpha-crystallin B chain, epididymis secretory protein Li 101, heat shock protein beta-5, heat shock protein family B member 5, heat-shock 20 kD like-protein, renal carcinoma antigen NY-REN-27, rosenthal fiber component

Rabbit

IgG

Alpha-crystallin B chain

Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into alpha, beta and gamma families, and the beta- and gamma-crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions, inclu-ding four homologous motifs, a connecting peptide, and N- and C-terminal extensions. alpha-crystallins consist of three gene products, alphaA-, alphaB- and alphaC-crystallin, which are members of the small heat shock protein family (HSP 20). alpha-crystallins act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, alpha-crystallins do not renature these proteins. Expression of alphaA-crystallin is restricted to the lens and defects of this gene cause the development of autosomal dominant congenital cataracts (ADCC). The human alphaB-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of alphaB-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.

Human, Rat

Human,Rat

-20°C,2°C to 8°C

41116161