Immunohistochemical staining of formalin fixed and paraffin embedded human Parkinsons Disease Brain [40X] tissue sections using Anti-alpha-synuclein antibody (RM492) at 1:100 dilution.
Immunohistochemical staining of formalin fixed and paraffin embedded human Parkinsons Disease Brain [40X] tissue sections using Anti-alpha-synuclein antibody (RM492) at 1:100 dilution.
anti-alpha-synuclein (SYUA), Rabbit Monoclonal (RM492)
REV-31-1384-00
Product group Antibodies
Overview
- SupplierRevMAb Biosciences
- Product Nameanti-alpha-synuclein (SYUA), Rabbit Monoclonal (RM492)
- Delivery Days Customer10
- CertificationResearch Use Only
- ClonalityMonoclonal
- Scientific DescriptionAlpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinsons disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body. - Recombinant Antibody. RM492 reacts to human, mouse or rat alpha-Synuclein (SYUA). Isotype: Rabbit IgG. Immunogen: A peptide corresponding to residues near the C-terminus of human alpha-Synuclein. Applications: IHC, WB. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinsons disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203