Anti-AMPK gamma 1 Mouse mAb

PTM BIO

Anti-AMPK gamma 1 Mouse mAb

5

Western Blot

WB

Research Use Only

Monoclonal

12813

Unconjugated

Mouse

IgG

5'-AMP-activated protein kinase subunit gamma-1

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct Phosphorylatedrylation of metabolic enzymes, and by longer-term effects via Phosphorylatedrylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing Phosphorylatedrylation and preventing dePhosphorylatedrylation of catalytic subunits. ADP also stimulates Phosphorylatedrylation, without stimulating already Phosphorylatedrylated catalytic subunit. ATP promotes dePhosphorylatedrylation of catalytic subunit, rendering the AMPK enzyme inactive.

Stable for 12 months from date of receipt/reconstitution.

Mouse, Rat

Mouse, Rat

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203