Anti-Angiogenin [26-2F]

Absolute Antibody

Anti-Angiogenin [26-2F]

9

The antibody binds specifically to angiogenin, a member of of the ribonuclease superfamily of proteins, which interacts with actin on the surface of endothelial and smooth muscle cells, inducing neovascularization. Due to its angiogenic activity, angiogenesis plays a key role in the growth and invasiveness of tumour cells, and therefore neutralising monoclonal antibodies such as 26-2F are important anticancer drugs. The monoclonal antibody 26-2F is not directly cytotoxic to tumour cells in vitro, however has been shown to have antagonistic effects in human breast cancer xenografts in athymic mice.

ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, Neutralisation/Blocking

Research Use Only

Monoclonal

26-2F

ANG

angiogenin

ALS9; angiogenin; angiogenin, ribonuclease, RNase A family, 5; epididymis luminal protein 168; HEL168; RAA1; ribonuclease 5; ribonuclease A A1; ribonuclease A family member 5; RNase 5; RNASE4; RNASE5

Mouse

IgG1

Angiogenin

-20°C,2°C to 8°C

12352203