Anti-Angiotensin II Type 2 Receptor Antibody [SN71-03]

HUABIO

Anti-Angiotensin II Type 2 Receptor Antibody [SN71-03]

7

ImmunoPrecipitation, Western Blot

WB,IP

Research Use Only

Monoclonal

SN71-03

1 mg/ml

Unconjugated

AGTR2

angiotensin II receptor type 2

AT2, ATGR2, MRX88, type-2 angiotensin II receptor, AT2 receptor, angiotensin II type-2 receptor

Rabbit

IgG

Type-2 angiotensin II receptor

Angiotensin II (Ang II) is an important physiological effector of blood pressure and volume regulation through vasoconstriction, aldosterone release, sodium uptake and thirst stimulation. Although Ang II interacts with two types of cell surface receptors, AT1 and AT2, most of the major cardiovascular effects seem to be mediated through AT1. Molecular cloning of the AT1 protein has shown it to be a member of the G protein-associated seven transmembrane protein receptor family. Ang II treatment of cells results in activation of several signal transduction pathways as evidenced by tyrosine phosphorylation of several proteins and induction of others. PLCgamma is phosphorylated after 30 seconds of treatment with Angiotensin II, indicating this as an early signal transduction event. Ang II treatment also stimulates phosphorylation of Shc, FAK and MAP kinases, and induces MKP-1, indicating stimulation of growth factor pathways. Ang II stimulation through AT1 has been shown to activate the JAK/Stat pathway involving a direct interaction between JAK2 and AT1 as demonstrated by coimmunoprecipitation. The AT1 receptor has no cytoplasmic kinase domain, but is able to function as a substrate for Src kinases and has several putative phosphorylation sites.

Human

Human

Mouse,Rat

-20°C,2°C to 8°C

41116161