Anti-APE1 Antibody [12H1]

HUABIO

Anti-APE1 Antibody [12H1]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,FC

Research Use Only

Monoclonal

12H1

2 mg/ml

Unconjugated

APEX1

apurinic/apyrimidinic endodeoxyribonuclease 1

APE, APE1, APEN, APEX, APX, HAP1, REF1, DNA repair nuclease/redox regulator APEX1, AP endonuclease class I, AP lyase, APEX nuclease (multifunctional DNA repair enzyme) 1, DNA-(apurinic or apyrimidinic site) endonuclease, DNA-(apurinic or apyrimidinic site) lyase, apurinic-apyrimidinic endonuclease 1, apurinic/apyrimidinic (abasic) endonuclease, deoxyribonuclease (apurinic or apyrimidinic), protein REF-1, redox factor-1

Mouse

IgG2a

DNA repair nuclease/redox regulator APEX1

The role of transcription factors in the regulation of gene expression is well established. Although the activity of these factors can be regulated by phosphorylation, evidence has indicated regulation of DNA binding mediated by changes in reduction-oxidation (redox) status. Mutational analysis has identified a single conserved cysteine residue mapping within the DNA binding domains of Fos and Jun. Chemical oxidation or modification of this cysteine residue inhibits the DNA binding activity of Fos and Jun. A similar mode of regulation has been recently proposed for other nuclear transcription factors. Oxidation is reversible by these compounds or by a cellular redox/DNA repair protein identified originally as Ref-1 (redox factor 1). Ref-1 is identical to a previously characterized DNA repair enzyme designated HAP1, APE or APEX.

Human, Mouse

Human,Mouse

-20°C,2°C to 8°C

41116161