Anti-ATG7 Antibody [SC06-30]

HUABIO

Anti-ATG7 Antibody [SC06-30]

7

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,IP,FC

Research Use Only

Monoclonal

SC06-30

1 mg/ml

Unconjugated

ATG7

autophagy related 7

APG7-LIKE, APG7L, GSA7, SCAR31, ubiquitin-like modifier-activating enzyme ATG7, APG7 autophagy 7-like, ATG12-activating enzyme E1 ATG7, hAGP7, ubiquitin-activating enzyme E1-like protein

Rabbit

IgG

Ubiquitin-like modifier-activating enzyme ATG7

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner.

Human, Mouse

Human,Mouse

-20°C,2°C to 8°C

41116161