Anti-ATF6 Antibody [8D3]

HUABIO

Anti-ATF6 Antibody [8D3]

7

ImmunoFluorescence, Western Blot

WB,IHC-P,FC

Research Use Only

Monoclonal

8D3

2 mg/ml

Unconjugated

ATF6

activating transcription factor 6

ACHM7, ATF6A, ATP6alpha, cyclic AMP-dependent transcription factor ATF-6 alpha, cAMP-dependent transcription factor ATF-6 alpha

Mouse

IgG1

Cyclic AMP-dependent transcription factor ATF-6 alpha

Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5-CCAC[GA]-3half of the ER stress response element (ERSE) (5-CCAAT-N9-CCAC[GA]-3) and of ERSE II (5-ATTGG-N-CCACG-3). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161