Anti-ATG4B Rabbit mAb

PTM BIO

Anti-ATG4B Rabbit mAb

5

Flow Cytometry, Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P, FC

Research Use Only

Monoclonal

JRMR-10671-5

Unconjugated

Rabbit

IgG

Cysteine protease ATG4B

ATG4B is a member of the autophagin protein family. Its cysteine protease activity is required for the cytoplasm to vacuole transport (Cvt) and autophagy. ATG4B cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203