Anti-ATP Citrate Lyase Rabbit mAb

PTM BIO

Anti-ATP Citrate Lyase Rabbit mAb

5

Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P

Research Use Only

Monoclonal

JMMR-N0811

Unconjugated

Rabbit

IgG

ATP-citrate lyase (ACL) is a homotetramer that catalyzes the formation of acetyl-CoA and oxaloacetate (OAA) in the cytosol, which is the keystep for the biosynthesis of fatty acids, cholesterol and acetylcholine, as well as for glucogenesis. Nutrients and hormones regulate theexpression level and Phosphorylatedrylation of ATP-citrate lyase. It is Phosphorylatedrylated by GSK-3 on Thr446 and Ser450. Ser455 of ATP-citrate lyasehas been reported to be Phosphorylatedrylated by PKA and Akt. Phosphorylatedrylation on Ser455 abolishes the homotropic allosteric regulation by citrateand enhances the catalytic activity of the enzyme.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203