Anti-Axin2 Antibody [JM11-30]

HUABIO

Anti-Axin2 Antibody [JM11-30]

7

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P

Research Use Only

Monoclonal

JM11-30

1 mg/ml

Unconjugated

AXIN2

axin 2

AXIL, ODCRCS, axin-2, axin-like protein, axis inhibition protein 2, conductin

Rabbit

IgG

Axin-2

b-catenin is a component of both the cadherin cell adhesion system and the Wnt signaling pathway. Wnt signaling increases the amount of b-catenin, by preventing its ubiquitination and degradation, allowing its direct interaction with transcription factors of the lymphoid enhancer factor-T cell factor family and modulation of gene expression. Axin is involved in the degradation of b-catenin by acting as a scaffold to form a complex between b-catenin, adenomatous polyposis coli (APC) and GSK-3b. APC, which is phosphorylated by GSK-3b, induces degradation of b-catenin, thus inhibiting Wnt signal transduction. Conductin is 45% identical to axin and appears to play a similar role to axin in the Wnt signaling pathway.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161