Anti-B7-H4(VTCN1) Antibody

HUABIO

Anti-B7-H4(VTCN1) Antibody

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,FC

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

VTCN1

V-set domain containing T cell activation inhibitor 1

B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1, V-set domain-containing T-cell activation inhibitor 1, B7 family member, H4, B7 homolog 4, B7 superfamily member 1, T cell costimulatory molecule B7x, immune costimulatory protein B7-H4

Rabbit

IgG

V-set domain containing T-cell activation inhibitor 1

T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4, also designated VTCN1), belongs to the B7 Immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells supresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.

Human, Mouse

Human,Mouse

-20°C,2°C to 8°C

41116161