Anti-Bag3 Antibody [JA90-53]

HUABIO

Anti-Bag3 Antibody [JA90-53]

7

ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P,IP

Research Use Only

Monoclonal

JA90-53

1 mg/ml

Unconjugated

BAG3

BAG cochaperone 3

BAG-3, BIS, CAIR-1, CMD1HH, CMT2JJ, HMND15, MFM6, BAG family molecular chaperone regulator 3, BCL2 associated athanogene 3, BCL2-binding athanogene 3, Bcl-2-binding protein BIS transcript 2, bcl-2-binding protein Bis, docking protein CAIR-1

Rabbit

IgG

BAG family molecular chaperone regulator 3

The Bag family of proteins are characterized by the presence of a 45 amino acid Bag domain through which they bind with high affinity to the ATPase domain of HSP 70, thereby negatively regulating HSP 70 chaperone activity. Bag-3 (Bcl-2-associated athanogene 3), also known as BIS or CAIR-1, is a 575 amino acid protein that contains one C-terminal Bag domain and two N-terminal WW domains. Like other members of the Bag family, Bag-3 functions to inhibit the chaperone activity of HSP 70, specifically by promoting the release of HSP 70-bound substrates. Additionally, Bag-3 exhibits anti-apoptotic activity via cell cycle control, suggesting a possible role for Bag-3 in tumor progression. The gene encoding Bag-3 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.

Human

Human

-20°C,2°C to 8°C

41116161