Anti-Bcl-1/cyclin D1 (5D4) Mouse IgG MoAb

IBL Japan

Anti-Bcl-1/cyclin D1 (5D4) Mouse IgG MoAb

7

Cross-react with cyclin D2

Western Blot, ImmunoHistoChemistry

WB, IHC

Research Use Only

5D4

Bcl-1/Cyclin D1 belongs to the G1 cyclins and plays a key role in cell cycle regulation during the G1/S transition by cooperating with cyclin-dependent kinases (CDKs). Its overexpression may lead to growth advantage for tumor cells by way of cell cycle progression, and actually it has been reported in various human cancers, e.g., esophageal, breast, and bladder carcinomas. Among hematolymphoid malignancies, cyclin D1 overexpression resulting from translocational activation has also been recognized in a subset of B-chronic lymphocytic leukemia (B-CLL), multiple myeloma, splenic marginal zone lymphoma, hairy cell leukemia, and mantle cell lymphoma.

12352203