Anti-beta 2 Microglobulin Antibody [SU35-05]

HUABIO

Anti-beta 2 Microglobulin Antibody [SU35-05]

7

ImmunoFluorescence, Western Blot

WB,IF-Cell,IP

Research Use Only

Monoclonal

SU35-05

1 mg/ml

Unconjugated

B2M

beta-2-microglobulin

AMYLD6, IMD43, MHC1D4, beta-2-microglobulin, beta chain of MHC class I molecules, beta-2-microglobin

Rabbit

IgG

Beta-2-microglobulin

beta2 microglobulin also known as B2M is a component of MHC class I molecules, MHC class I molecules have alpha1, alpha2, and alpha3 proteins which are present on all nucleated cells (excludes red blood cells). In humans, the beta2 microglobulin protein is encoded by the B2M gene. beta2 microglobulin associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 (5 genes in humans), MR1, the neonatal Fc receptor (FcRn), and Qa-1 (a form of alloantigen). Nevertheless, the beta2 microglobulin gene is outside of the MHC (HLA) locus, on a different chromosome. An additional function is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the basolateral membrane of enterocytes and cell membrane of macrophages for degradation resulting in decreased iron uptake from food and decreased iron release from recycled red blood cells in the MPS (mononuclear phagocyte system) respectively. Loss of this function causes iron excess and hemochromatosis. In cytomegalovirus infection, a viral protein binds to beta2 microglobulin, preventing assembly of MHC class I molecules and their transport to the plasma membrane.

Human

Human

Mouse,Rat

-20°C,2°C to 8°C

41116161