Anti-beta Actin Antibody [A2-F6]

HUABIO

Anti-beta Actin Antibody [A2-F6]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,FC

Research Use Only

Monoclonal

A2-F6

2 mg/ml

Unconjugated

ACTB

actin beta

BKRNS, BNS, BRWS1, CSMH, DDS1, PS1TP5BP1, THC8, actin, cytoplasmic 1, I(2)-actin, PS1TP5-binding protein 1, beta cytoskeletal actin

Mouse

IgG1

Actin, cytoplasmic 1

Beta-actin (human gene and protein abbreviation ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins[5][6] that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus. Beta-actin has been shown to interact with SPTBN2. In addition, RNA-binding protein Sam68 was found to interact with the mRNA encoding beta-actin, which regulates the synaptic formation of the dendritic spines with its cytoskeletal components. Beta-actin has been shown to activate eNOS, thereby increasing NO production. An eight-amino acid residue (326-333) in actin has been shown to mediate the interaction between actin and eNOS. Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma. Beta actin is often used in Western blotting as a loading control, to normalize total protein amounts and check for eventual protein degradation in the samples. Its transcript is also commonly used as a housekeeping gene standard in qPCR. Its molecular weight is approximately 42 kDa.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161