anti-beta Amyloid (1 - 42) antibody [CA9 10C11] (Biotin)

Arigo Biolaboratories

anti-beta Amyloid (1 - 42) antibody [CA9 10C11] (Biotin)

23

ELISA

Research Use Only

Monoclonal

CA9 10C11

Biotin

App

amyloid beta precursor protein

Abeta; ABPP; AG; alzheimer disease amyloid A4 protein homolog; amyloid A4; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloid precursor protein; amyloid-beta A4 protein; amyloidogenic glycoprotein; beta-amyloid precursor protein

Mouse

IgG2b

Amyloid beta peptide 42 (Abeta42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimers disease. Abeta42 and Abeta40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. Abeta42 (42 amino acids) is very fibrillogenic. The beta pleated structure of Abeta42 constituents the initial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that Abeta42 contributes to the pathogenesis of Alzheimers disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheimers disease. Another is that the neurotoxicity of Abeta42 oligomer is the cause of the disease.

-20°C

12352203