Anti-beta-Arrestin 1 Mouse mAb

PTM BIO

Anti-beta-Arrestin 1 Mouse mAb

5

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin

WB, IHC-P, ICC/IF

Research Use Only

Monoclonal

JMMR-2675

Unconjugated

Mouse

IgG

Beta-arrestin-1

Beta-Arrestin 1 is one of bèta-Arrestins (ARRBs), the best-known negative regulators of G protein-coupled receptor signaling. bèta-Arrestins are versatile and multifunctional adapter proteins that regulate diverse cellular functions, including cell growth, apoptosis and immune responses. Overexpression of beta-Arrestin 1 has been found in various cancers, indicating it is a potential therapeutic target for cancer treatment. Recently, expression of beta-Arrestin 1 in saliva has been identified as a candidate circadian biomarker. Erk1/2 constitutively Phosphorylatedrylates beta-Arrestin 1 at carboxy-terminal Ser412, which promotes cytosolic localization of the scaffold protein. DePhosphorylatedrylation is an essential step of beta-Arrestin 1-mediated receptor endocytosis, but it is not required for receptor desensitization.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203