Anti-bèta-Hydroxybutyryl-Histone H2B (Lys12) Rabbit pAb

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Anti-bèta-Hydroxybutyryl-Histone H2B (Lys12) Rabbit pAb

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Anti-bèta-Hydroxybutyrylated-Histone H2B (Lys12) Rabbit pAb detects histone H2B only when it is bèta-hydroxybutyrylated at Lys12.

Western Blot

WB

Antibody

Research Use Only

Polyclonal

Unconjugated

Rabbit

IgG

Histone H2B type 1-C/E/F/G/I

Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, Phosphorylatedrylation, ubiquitination, etc. bèta-Hydroxybutyrylation of lysine (Kbhb) is a newly identified histone marker that is enriched in active gene promoters. Histone Kbhb marks are dramatically induced in response to elevated bèta-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prolonged fasting or streptozotocin-induced diabetic ketoacidosis. Histone bèta-hydroxybutyrylation represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of bèta-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein A and immunogen affinity purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203