Anti-BIN1 Antibody [JE34-92]

HUABIO

Anti-BIN1 Antibody [JE34-92]

2

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

JE34-92

1 mg/ml

Unconjugated

BIN1

bridging integrator 1

AMPH2, AMPHL, CNM2, SH3P9, myc box-dependent-interacting protein 1, amphiphysin 2, amphiphysin II, amphiphysin-like protein, box dependant MYC interacting protein 1, box-dependent myc-interacting protein 1

Rabbit

IgG

Myc box-dependent-interacting protein 1

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.

-20°C,2°C to 8°C

41116161