Anti-Bov CD18 Alexa Fluor(r) 488

EXBIO

Anti-Bov CD18 Alexa Fluor(r) 488

7

Flow cytometry: Recommended dilution: 2-5 microg/ml

Flow Cytometry, ImmunoCytoChemistry

Research Use Only

IVA35

0.5 mg/ml

AlexaFluor 488

IgG1

CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.

Bovine, Human

2°C to 8°C

12352203