Anti-BTK Mouse mAb

PTM BIO

Anti-BTK Mouse mAb

5

Western Blot

WB

Research Use Only

Monoclonal

12300

Unconjugated

Mouse

IgG

Tyrosine-protein kinase BTK

Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, Phosphorylatedrylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 Phosphorylatedrylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense.

Stable for 12 months from date of receipt/reconstitution.

Human

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203