Anti-C3a-receptor [2A1]

Absolute Antibody

Anti-C3a-receptor [2A1]

9

This antibody binds the 2e loop of the human C3a receptor, amino acid residues 185-199 and 218-226 (TNDHPWTVP).

The original scFv antibody binds to the 2e loop of the human C3a receptor in an ELISA. Human C3a receptor is a G protein-coupled receptor stimulating chemotaxis, superoxide anion generation and granule enzyme release. This antibody was able to bind RBL-2H3 cells stably expressing the C3aR and to the human mast cell line HMC-1 in a flow cytometric assay. This antibody is not capable of blocking the interaction between C3a and C3aR (PMID: 11373092).

Flow Cytometry, ELISA

Research Use Only

Monoclonal

2A1

C3AR1

complement C3a receptor 1

AZ3B; C3a anaphylatoxin chemotactic receptor; C3AR; complement component 3 receptor 1; complement component 3a receptor 1; HNFAG09

Mouse

IgG2b

C3a anaphylatoxin chemotactic receptor

This full-length reformatted mouse antibody was made using the variable domain sequences of the original Mouse scFv format for improved compatibility with existing reagents assays and techniques.

Human

-20°C,2°C to 8°C

12352203