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ProductsBack/anti-Calponin-1, Rabbit Monoclonal (RM262)
Immunocytochemistry of HeLa cells, using Calponin-1 Rabbit Monoclonal Antibody (Clone RM262) (red). Actin filaments have been labeled with fluorescein phalloidin (green), and nucleus stained with DAPI (blue).
Immunocytochemistry of HeLa cells, using Calponin-1 Rabbit Monoclonal Antibody (Clone RM262) (red). Actin filaments have been labeled with fluorescein phalloidin (green), and nucleus stained with DAPI (blue).
Immunocytochemistry of HeLa cells, using Calponin-1 Rabbit Monoclonal Antibody (Clone RM262) (red). Actin filaments have been labeled with fluorescein phalloidin (green), and nucleus stained with DAPI (blue).

anti-Calponin-1, Rabbit Monoclonal (RM262)

Research Use Only
REV-31-1143-00
RevMAb Biosciences
ApplicationsWestern Blot, ImmunoCytoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse
TargetCNN1
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Overview

  • Supplier
    RevMAb Biosciences
  • Product Name
    anti-Calponin-1, Rabbit Monoclonal (RM262)
  • Delivery Days Customer
    5
  • Applications
    Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    RM262
  • Gene ID1264
  • Target name
    CNN1
  • Target description
    calponin 1
  • Target synonyms
    basic calponin; calponin 1, basic, smooth muscle; calponin H1, smooth muscle; calponin-1; calponins, basic; epididymis secretory protein Li 14; HEL-S-14; Sm-Calp; SMCC
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Calponin-1 is a 34 kDa thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It interacts with actin, tropomyosin and calmodulin. Calponin-1 binds actin to promote and sustain polymerization. The binding of calponin to F-actin inhibits the MgATPase activity of smooth muscle myosin. The expression of Calponion-1 is specific to differentiated mature smooth muscle cells, suggesting a role in contractile functions. It is up-regulated in smooth muscle tissues during postnatal development with a higher content in phasic smooth muscle of the digestive tract. Calponin-1 has been found to be useful in differentiating benign sclerosing lesions of the breast from carcinoma. Calponin-1 positivity has also been noted in malignant myoepithelioma and pleomorphic adenoma of salivary gland origin, as well as angiomatoid malignant fibrous histiocytoma. - Recombinant Antibody. This antibody reacts to human or mouse Calponin-1. Applications: WB, ICC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Calponin-1 is a 34 kDa thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It interacts with actin, tropomyosin and calmodulin. Calponin-1 binds actin to promote and sustain polymerization. The binding of calponin to F-actin inhibits the MgATPase activity of smooth muscle myosin. The expression of Calponion-1 is specific to differentiated mature smooth muscle cells, suggesting a role in contractile functions. It is up-regulated in smooth muscle tissues during postnatal development with a higher content in phasic smooth muscle of the digestive tract. Calponin-1 has been found to be useful in differentiating benign sclerosing lesions of the breast from carcinoma. Calponin-1 positivity has also been noted in malignant myoepithelioma and pleomorphic adenoma of salivary gland origin, as well as angiomatoid malignant fibrous histiocytoma.
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203