anti-Calponin-1, Rabbit Monoclonal (RM262)

RevMAb Biosciences

anti-Calponin-1, Rabbit Monoclonal (RM262)

10

Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

RM262

CNN1

calponin 1

basic calponin; calponin 1, basic, smooth muscle; calponin H1, smooth muscle; calponin-1; calponins, basic; epididymis secretory protein Li 14; HEL-S-14; Sm-Calp; SMCC

Rabbit

IgG

Calponin-1

Calponin-1 is a 34 kDa thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It interacts with actin, tropomyosin and calmodulin. Calponin-1 binds actin to promote and sustain polymerization. The binding of calponin to F-actin inhibits the MgATPase activity of smooth muscle myosin. The expression of Calponion-1 is specific to differentiated mature smooth muscle cells, suggesting a role in contractile functions. It is up-regulated in smooth muscle tissues during postnatal development with a higher content in phasic smooth muscle of the digestive tract. Calponin-1 has been found to be useful in differentiating benign sclerosing lesions of the breast from carcinoma. Calponin-1 positivity has also been noted in malignant myoepithelioma and pleomorphic adenoma of salivary gland origin, as well as angiomatoid malignant fibrous histiocytoma. - Recombinant Antibody. This antibody reacts to human or mouse Calponin-1. Applications: WB, ICC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. Calponin-1 is a 34 kDa thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It interacts with actin, tropomyosin and calmodulin. Calponin-1 binds actin to promote and sustain polymerization. The binding of calponin to F-actin inhibits the MgATPase activity of smooth muscle myosin. The expression of Calponion-1 is specific to differentiated mature smooth muscle cells, suggesting a role in contractile functions. It is up-regulated in smooth muscle tissues during postnatal development with a higher content in phasic smooth muscle of the digestive tract. Calponin-1 has been found to be useful in differentiating benign sclerosing lesions of the breast from carcinoma. Calponin-1 positivity has also been noted in malignant myoepithelioma and pleomorphic adenoma of salivary gland origin, as well as angiomatoid malignant fibrous histiocytoma.

-20°C

12352203