Anti-Canine Lymphoma [Mab231]

Absolute Antibody

Anti-Canine Lymphoma [Mab231]

7

This antibody binds canine lymphoma cells.

This antibody is recommended for detection of canine lymphoma cells. The binding ability of the hybridoma supernatents with canine lymphoma cells was determined by radioimmunoassay. FACS analysis was used to analyse the binding of the antibody to cells freshly isolated from canine lymphomatous nodes and normal lymphocytes of canine and human blood (Steplewski et al., 1987). This antibody has been shown to exhibit antibody-dependent cellular cytotoxicity as well as complement-dependant cytolysis (Rosales et al., 1988). Canine lymphoma is conventionally treated with chemotherapy, but it was found that subsequent treatment with a specific monoclonal antibody, Mab 231, raised against the lymphoma, substantially prolonged remission and survival times (Jeglum, 1989).

Flow Cytometry, RadioImmunoAssay

RIA; FC

Research Use Only

Monoclonal

Mab231

Rabbit

IgG

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Canine, Human

Dog, Human

The original antibody was generated by immunizing BALB/c mice with cannine lymphoma cell line 17-71.

-20°C,2°C to 8°C

12352203