anti-CASC5 antibody

Arigo Biolaboratories

anti-CASC5 antibody

23

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

Unconjugated

KNL1

kinetochore scaffold 1

AF15Q14; ALL1-fused gene from chromosome 15q14 protein; blinkin, bub-linking kinetochore protein; cancer susceptibility candidate 5; cancer susceptibility candidate gene 5 protein; cancer/testis antigen 29; CASC5; CT29; D40; hKNL-1; hSpc105; kinetochore 1 homolog; kinetochore scaffold 1; kinetochore- protein 1; MCPH4; microcephaly, primary autosomal recessive 4; PPP1R55; protein phosphatase 1, regulatory subunit 55; Spc7

Rabbit

IgG

The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013]

-20°C

12352203