Anti-Caspase-10 Antibody [JJ0890]

HUABIO

Anti-Caspase-10 Antibody [JJ0890]

7

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P,FC,IP

Research Use Only

Monoclonal

JJ0890

1 mg/ml

Unconjugated

CASP10

caspase 10

ALPS2, FLICE-2, FLICE2, MCH4, caspase-10, CASP-10, FADD-like ICE2, FAS-associated death domain protein interleukin-1B-converting enzyme 2, ICE-like apoptotic protease 4, apoptotic protease MCH-4, caspase 10 apoptosis-related cysteine peptidase, caspase 10, apoptosis-related cysteine protease, interleukin-1B-converting enzyme 2

Rabbit

IgG

Caspase-10

Caspase-10, also designated Mch4, is recruited to the native TRAIL and CD9 death-inducing signaling complexes (DISCs) by the FADD/Mort1 adaptor protein complex. Caspase-10 requires the assembly of the FADD and DISC complexes for its recruitment and cleavage-induced activation during CD95-induced apoptosis of activated T cells. The N-terminus of caspase-10 contains FADD-like death effector domains further indicating that it associates with FADD to induce apoptosis. Caspase-10 is not required for apoptosis induction and when overexpressed, cannot reverse defects in apoptosis induction caused by caspase-8 deficiency. Granzyme B cleaves procaspase-10 at an IXXD-A processing sequence to produce mature caspase-10. Mutations in the caspase-10 gene in the prodomain, p17 large protease subunit and p12 small protease subunit have been linked to a number of non-Hodgkin lymphomas in humans.

Human

Human

-20°C,2°C to 8°C

41116161