Western blot using anti-Caspase-11 (mouse), mAb (8A5) (Prod. No. AG-20T-0139) detecting endogenous caspase-11 in mouse spleen and lymph node as two bands of 43 and 38 kDa after exposure to LPS.
Western blot using anti-Caspase-11 (mouse), mAb (8A5) (Prod. No. AG-20T-0139) detecting endogenous caspase-11 in mouse spleen and lymph node as two bands of 43 and 38 kDa after exposure to LPS.
anti-Caspase-11 (mouse), mAb (8A5)
AG-20T-0139
ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot, ELISA
Product group Antibodies
ReactivityMouse, Rat
TargetCasp4
Overview
- SupplierAdipoGen Life Sciences
- Product Nameanti-Caspase-11 (mouse), mAb (8A5)
- Delivery Days Customer10
- Antibody SpecificityRecognizes mouse and rat full-length caspase-11 protein. Detects two bands of ~38kDa and ~43kDa by Western blot.
- ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot, ELISA
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID8A5
- Concentration1 mg/ml
- Estimated Purity>95%
- FormulationLiquid
- Gene ID12363
- Target nameCasp4
- Target descriptioncaspase 4, apoptosis-related cysteine peptidase
- Target synonymsCas; Casp11; CASP-11; CASP-4; Caspa; caspase 11, apoptosis-related cysteine peptidase; caspase 11, apoptosis-related cysteine protease; caspase 4, apoptosis-related cysteine protease; caspase-11 short form splicing; caspase-4; Caspl; ich-; ich-3; protease ICH-3
- HostRat
- IsotypeIgG1
- Protein IDP70343
- Protein NameCaspase-4
- Scientific DescriptionCaspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7. - Monoclonal Antibody. Recognizes mouse and rat full-length caspase-11 protein. Detects two bands of ~38kDa and ~43kDa by Western blot. Isotype: Rat IgG1kappa. Clone: 8A5. Applications: ELISA, FACS, IP, WB. Liquid. In PBS containing 0.02% sodium azide. Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7.
- ReactivityMouse, Rat
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203