Anti-Caspase-6 Rabbit mAb

PTM BIO

Anti-Caspase-6 Rabbit mAb

5

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin

WB, IHC-P, ICC/IF

Research Use Only

Monoclonal

11283

Unconjugated

Rabbit

IgG

Caspase-6

Caspase-6 is an Cysteine protease that is encoded by the CASP6 gene in human. During apoptosis, it localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA, thereby inducing nuclear shrinkage and fragmentation. Furthermore, it cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP. In addition, Caspase-6 promotes the ZBP1-mediated activation of programmed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis) and plays an essential role in defense against viruses. Mechanistically, Caspase-6 interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death. Caspase-6 has known functions in apoptosis, early immune response and neurodegeneration in Huntington's and Alzheimer's disease.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203