Anti-CBARA1 Antibody

HUABIO

Anti-CBARA1 Antibody

7

Western Blot

WB

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

MICU1

mitochondrial calcium uptake 1

CALC, CBARA1, EFHA3, MPXPS, ara CALC, calcium uptake protein 1, mitochondrial, atopy-related autoantigen CALC, calcium-binding atopy-related autoantigen 1

Rabbit

IgG

Calcium uptake protein 1, mitochondrial

Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. Alternatively spliced transcript variants encoding different isoforms have been described.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161