Anti-CCDC98 Antibody [JE62-73]

HUABIO

Anti-CCDC98 Antibody [JE62-73]

2

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

JE62-73

1 mg/ml

Unconjugated

ABRAXAS1

abraxas 1, BRCA1 A complex subunit

ABRA1, CCDC98, FAM175A, BRCA1-A complex subunit Abraxas 1, abraxas protein, coiled-coil domain containing 98, family with sequence similarity 175 member A

Rabbit

IgG

BRCA1-A complex subunit Abraxas 1

This gene encodes a protein that binds to the C-terminal repeats of breast cancer 1 (BRCA1) through a phospho-SXXF motif. The encoded protein recruits ubiquitin interaction motif containing 1 protein to BRCA1 protein and is required for DNA damage resistance, DNA repair, and cell cycle checkpoint control. Pseudogenes of this gene are found on chromosomes 3 and 8. Alternative splicing results in multiple transcript variants. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX.

-20°C,2°C to 8°C

41116161