Anti-CCR2 [4.9]

Absolute Antibody

Anti-CCR2 [4.9]

7

This antibody specifically binds an epitope located within the 2nd extracellular loop of human CCR2. The human C-C chemokine receptor type 2 is a key functional receptor for CCL2 but can also bind CCL7 and CCL12.

The binding specificity of this antibody to full length CCR2, and 1St and 2nd loop of CCR2 was determined using ELISA. The binding reactivity of this antibody to the surface bound CCR2 receptors was confirmed with flow cytometry. This antibody can positively inhibit chemotaxis of THP-1 monocytes. The therapeutic effects of this antibody were studied in in vivo mouse models of inflammation, multiple sclerosis and neuropathic pain (US8710191).

Flow Cytometry, ELISA, Other Application

FC; ELISA; antagonist

Research Use Only

Monoclonal

4.9

CCR2

C-C motif chemokine receptor 2

C-C chemokine receptor type 2; CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; chemokine (C-C motif) receptor 2; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1 receptor; MCP-1-R; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor

Rabbit

IgG

C-C chemokine receptor type 2

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Human

Human

The original antibody was generated by immunizing human immunoglobulin generating XENOMOUSE mice with human CCR2 antigen.

-20°C,2°C to 8°C

12352203