Anti-CD112 [Nec1-554-1]

Absolute Antibody

Anti-CD112 [Nec1-554-1]

9

The binding of this antibody to CD112 or Nectin-2 expressed on the surface of CHO cells was determined using whole cell ELISA. The cross reactivity of this antibody for cynomolgus monkey CD112 expressed on CHO-K1 cells was checked using flow cytometry. This antibody shows good ADCC activity against OV-90, MDA-MB-231, NCI-H1299, Du145 and U937 cell lines. The in-vivo anti-tumor activity of this antibody was tested in nude mice models transplanted with OV-90 human ovarian cancer cell line. This antibody showed T/C (Treatment/Control) value of 34%. The in-vivo activity was also checked in SCID mouse models for treating lung metastasis with MDA-MB-231 human breast cancer cell line (US20100008928).

Functional Assay, Flow Cytometry, ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

Nec1-554-1

NECTIN2

nectin cell adhesion molecule 2

CD112, HVEB, PRR2, PVRL2, PVRR2, nectin-2, herpesvirus entry protein B, poliovirus receptor-like 2, poliovirus receptor-related 2 (herpesvirus entry mediator B)

Human

IgG1

Nectin-2

-20°C,2°C to 8°C

12352203