Anti-CD11b Antibody [A2-B5-D2]

HUABIO

Anti-CD11b Antibody [A2-B5-D2]

7

Western Blot

WB,FC

Research Use Only

Monoclonal

A2-B5-D2

2 mg/ml

Unconjugated

ITGAM

integrin subunit alpha M

CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6, integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, antigen CD11b (p170), cell surface glycoprotein MAC-1 subunit alpha, complement component 3 receptor 3 subunit, integrin, alpha M (complement component 3 receptor 3 subunit), leukocyte adhesion receptor MO1, macrophage antigen alpha polypeptide, macrophage-1 antigen alpha subunit, neutrophil adherence receptor alpha-M subunit

Mouse

IgM

Integrin alpha-M

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (By similarity). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development .

Human, Mouse

Human,Mouse

-20°C,2°C to 8°C

41116161