Anti-CD11c Antibody [SI19-06]

HUABIO

Anti-CD11c Antibody [SI19-06]

7

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application

WB,IHC-P,IP

Research Use Only

Monoclonal

SI19-06

1 mg/ml

Unconjugated

ITGAX

integrin subunit alpha X

CD11C, SLEB6, integrin alpha-X, CD11 antigen-like family member C, complement component 3 receptor 4 subunit, integrin alpha X, integrin, alpha X (antigen CD11C (p150), alpha polypeptide), integrin, alpha X (complement component 3 receptor 4 subunit), leu M5, alpha subunit, leukocyte adhesion glycoprotein p150,95 alpha chain, leukocyte adhesion receptor p150,95, leukocyte surface antigen p150,95, alpha subunit, myeloid membrane antigen, alpha subunit, p150 95 integrin alpha chain

Rabbit

IgG

Integrin alpha-X

Integrin alphaX (CD11C, leukocyte surface antigen p150,95, CR4, Axb2) is a type 1 transmembrane protein that traditionally combines with beta2 chain to form a leukocyte-specific integrin known as inactivated-C3b (iC3b) receptor 4 (CR4). Integrin alphaX/beta2 shares similar properties of the alphaM/beta2 integrin in mediating adherence of neutrophils and monocytes to stimulated endothelial cells, and in phagocytosis of complement coated particles. Abnormal expression of Integrin alphaX is characteristic of hairy cell leukemia (HCL) and is dependent upon activation of proto-oncogenes Ras and JunD. Proteins and DNA elements that influence transcription of Integrin alphaX include Sp1 and Sp1-like factors, AP-1 family, C/EBP, Oct-2 and PU.1. Integrin alphaX is present on monocyte derivative dendritic cells (DCs), macrophages and NK cells. Upon activation, DCs present in skin (Langerhans cells), lining of nose, lung, stomach, intestine and blood can migrate to lymphoid tissues and interact with T and B cells to initiate and shape the immune response.

Human

Human

-20°C,2°C to 8°C

41116161