Anti-CD137 Antibody [2G1]

HUABIO

Anti-CD137 Antibody [2G1]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P,IF-Cell,FC

Research Use Only

Monoclonal

2G1

2 mg/ml

Unconjugated

TNFRSF9

TNF receptor superfamily member 9

4-1BB, CD137, CDw137, ILA, IMD109, tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor, CD137 antigen, T cell antigen ILA, T-cell antigen 4-1BB homolog, homolog of mouse 4-1BB, induced by lymphocyte activation (ILA), interleukin-activated receptor, homolog of mouse Ly63, receptor protein 4-1BB

Mouse

IgG1

Tumor necrosis factor receptor superfamily member 9

CD137, also designated ILA and 4-1BB in mouse, belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. CD137 is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages, and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. Crosslinking of the CD137 ligand induces apoptosis in resting lymphocytes. In contrast, CD137 regulates peripheral monocyte survival by inducing a cytokine release profile, and is mediated by M-CSF and to a lesser extent by granulocyte-macrophage colony-stimulating factor and IL-3. Soluble forms of CD137 are found in sera from patients with rheumatoid arthritis and may provide a negative control mechanism for immune responses.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161