Bio-Connect

anti-CD244 [2B4] (human), mAb (2B4) (R-PE) (ANC244.8/8F7)

Research Use Only
ANC-239-050
Ancell Corporation
ApplicationsELISA, Flow Cytometry
Product group Antibodies
ReactivityHuman
TargetCD244
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Ancell Corporation
  • Product Name
    anti-CD244 [2B4] (human), mAb (2B4) (R-PE) (ANC244.8/8F7)
  • Delivery Days Customer
    10
  • Applications
    ELISA, Flow Cytometry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    ANC244.8/8F7
  • Conjugate
    RPE
  • Estimated Purity
    >95%
  • Gene ID51744
  • Target name
    CD244
  • Target description
    CD244 molecule
  • Target synonyms
    2B4; CD244 molecule, natural killer cell receptor 2B4; h2B4; NAIL; natural killer cell receptor 2B4; NK cell activation inducing ligand NAIL; NK cell activation-inducing ligand; NK cell type I receptor protein 2B4; NKR2B4; Nmrk; signaling lymphocytic activation molecule 4; SLAM family member 4; SLAMF4
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    CD244 (2B4; SLAMF4) is a 66kDa member of the CD2/SLAM related receptor family (SRR). It is expressed on NK, T cell subsets, monocytes and eosinophils. It is expressed at high levels on leuikemia initiating cells, and plays a role in their proliferative potential. In mice there are two transcription variants, a long form and a short form of CD244 each of which have distinct signaling properties. In humans, only the long form is expressed. Decreased CD244 expression on monocytes of SLE patients correlated (negatively) with autoantibody titer. CD244 mediated function in immune response can vary greatly dependant on the context of its ligation. - Monoclonal Antibody. Antibody ANC244.8 binds to recombinant CD244-muIg (#ANC-544-020) in EIA, and to cell surface CD244 on human PBL in FACS. ANC244.8 binds to a CD244 epitope that is distinct from the binding sites of clone ANC2B4/3B12 (#ANC-259-020). It blocks binding of clone C1.7. Applications: ELISA, FACS. Clone: ANC244.8/8F7. Isotype: Mouse IgG1kappa. 50mM Sodium Phosphate pH 7.5, 500mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2% BSA, 0.04% Sodium azide (as a preservative). CD244 (2B4; SLAMF4) is a 66kDa member of the CD2/SLAM related receptor family (SRR). It is expressed on NK, T cell subsets, monocytes and eosinophils. It is expressed at high levels on leuikemia initiating cells, and plays a role in their proliferative potential. In mice there are two transcription variants, a long form and a short form of CD244 each of which have distinct signaling properties. In humans, only the long form is expressed. Decreased CD244 expression on monocytes of SLE patients correlated (negatively) with autoantibody titer. CD244 mediated function in immune response can vary greatly dependant on the context of its ligation.
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203