anti-CD244 [2B4] (human), mAb (2B4) (Biotin) (ANC244.8/8F7)

Ancell Corporation

anti-CD244 [2B4] (human), mAb (2B4) (Biotin) (ANC244.8/8F7)

10

Flow Cytometry, ELISA

Research Use Only

Monoclonal

ANC244.8/8F7

1 mg/ml

Biotin

>95%

CD244

CD244 molecule

2B4; CD244 molecule, natural killer cell receptor 2B4; h2B4; NAIL; natural killer cell receptor 2B4; NK cell activation inducing ligand NAIL; NK cell activation-inducing ligand; NK cell type I receptor protein 2B4; NKR2B4; Nmrk; signaling lymphocytic activation molecule 4; SLAM family member 4; SLAMF4

Mouse

IgG1

Natural killer cell receptor 2B4

CD244 (2B4; SLAMF4) is a 66kDa member of the CD2/SLAM related receptor family (SRR). It is expressed on NK, T cell subsets, monocytes and eosinophils. It is expressed at high levels on leuikemia initiating cells, and plays a role in their proliferative potential. In mice there are two transcription variants, a long form and a short form of CD244 each of which have distinct signaling properties. In humans, only the long form is expressed. Decreased CD244 expression on monocytes of SLE patients correlated (negatively) with autoantibody titer. CD244 mediated function in immune response can vary greatly dependant on the context of its ligation. - Monoclonal Antibody. Antibody ANC244.8 binds to recombinant CD244-muIg (#ANC-544-020) in EIA, and to cell surface CD244 on human PBL in FACS. ANC244.8 binds to a CD244 epitope that is distinct from the binding sites of clone ANC2B4/3B12 (#ANC-259-020). It blocks binding of clone C1.7. Applications: ELISA, FACS. Clone: ANC244.8/8F7. Isotype: Mouse IgG1kappa. 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl, 5% Glycerol, 0.2% BSA, 0.04% Sodium azide (as a preservative). CD244 (2B4; SLAMF4) is a 66kDa member of the CD2/SLAM related receptor family (SRR). It is expressed on NK, T cell subsets, monocytes and eosinophils. It is expressed at high levels on leuikemia initiating cells, and plays a role in their proliferative potential. In mice there are two transcription variants, a long form and a short form of CD244 each of which have distinct signaling properties. In humans, only the long form is expressed. Decreased CD244 expression on monocytes of SLE patients correlated (negatively) with autoantibody titer. CD244 mediated function in immune response can vary greatly dependant on the context of its ligation.

2°C to 8°C

12352203