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anti-CD254 / RANKL antibody [IK22/5]

ARG23651
Arigo Biolaboratories
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityMouse
TargetTnfsf11
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Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-CD254 / RANKL antibody [IK22/5]
  • Delivery Days Customer
    23
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    IK22/5
  • Concentration
    0.5 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID21943
  • Target name
    Tnfsf11
  • Target description
    tumor necrosis factor (ligand) superfamily, member 11
  • Target synonyms
    Ly10; Ly109l; O; OD; ODF; OPG ligand; OPGL; osteoclast differentiation factor; osteoprotegerin ligand; R; RANKL; receptor activator of NF-kappaB ligand; receptor activator of nuclear factor kappa-B ligand; TNF-related activation-induced cytokine; Tra; Trance; tumor necrosis factor ligand superfamily member 11; tumor necrosis factor-related activation-induced cytokine
  • Host
    Rat
  • Isotype
    IgG2a
  • Scientific Description
    This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
  • Reactivity
    Mouse
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203