anti-CD274 [B7-H1/PD-L1] (human), mAb (ANC6H1) (R-PE)
ANC-274-050
ApplicationsFlow Cytometry, ELISA
Product group Antibodies
ReactivityHuman
Overview
- SupplierAncell Corporation
- Product Nameanti-CD274 [B7-H1/PD-L1] (human), mAb (ANC6H1) (R-PE)
- Delivery Days Customer10
- ApplicationsFlow Cytometry, ELISA
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDANC6H1
- ConjugateRPE
- FormulationLiquid
- HostMouse
- IsotypeIgG1
- Scientific DescriptionCD274 (B7-H1; PD-L1; Programmed Death Ligand) is a member of the B7 family and is expressed on a variety of tissues including lymphoid cells. It plays an important role in regulation of T cell activation and is involved in progression of cancer, arthritis and HIV infection. CD274 binding to its receptor CD279 (PD-1) on activated T cells can decrease proliferation. Conversely, ligation of CD279 on primed T cells can stimulate IL-10 production. High levels of CD274 present in renal cell carcinoma is associated with poor prognosis. Tumor expressed CD274 can increase apoptosis of tumor specific T cells resulting in better tumor cell survival. - Monoclonal Antibody. Isotype: Mouse IgG1kappa. Clone: ANC6H1. Applications: ELISA, FACS. 50 mM Sodium Phosphate pH 7.5, 500 mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2% BSA, 0.04% NaN3 (as a preservative). CD274 (B7-H1; PD-L1; Programmed Death Ligand) is a member of the B7 family and is expressed on a variety of tissues including lymphoid cells. It plays an important role in regulation of T cell activation and is involved in progression of cancer, arthritis and HIV infection. CD274 binding to its receptor CD279 (PD-1) on activated T cells can decrease proliferation. Conversely, ligation of CD279 on primed T cells can stimulate IL-10 production. High levels of CD274 present in renal cell carcinoma is associated with poor prognosis. Tumor expressed CD274 can increase apoptosis of tumor specific T cells resulting in better tumor cell survival.
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203